The East Coast's Main Street, Interstate 95 serves the entire Northeast Megalopolis, while also serving southeastern cities of Jacksonville and Miami along Florida's Space Coast. The highway is an important factor in commerce and tourism, linking scenic New England with the subtropical environs of southern Florida. It passes through more states than any other Interstate highway.

Interstate 95 also has more "child" routes than any other Interstate highway, and its spurs are generally much longer than those belonging to other routes (proposed routes are marked with a *):